Renin inhibitors: structural study regarding statine in linear oligopeptides
نویسندگان
چکیده
منابع مشابه
Statine-containing dipeptide and tripeptide inhibitors of human renin.
Dipeptide and tripeptide derivatives containing a statine residue were synthesized as inhibitors of human renin. ES-305, bis[(1-naphthyl)methyl]acetyl(BNMA)-histidyl-statine 2(S)-methylbutylamide was found to be a highly potent inhibitor of human renin with a Ki value of 1.7 X 10(-9) M. Dipeptide derivatives with the BNMA group at the N-terminal (BNMA-Val-Sta-isoleucinol [ES-313], BNMA-Leu-Sta-...
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15 صفحه اولHuman renin inhibitors.
facilitating distinction among the different types of aspartic proteinases. Thus, while considerable progress has been made in elucidating the structure, activity and importance (biological and commercial) of the aspartic proteinases, much remains to be learned about the distinctions in molecular architecture and how these are reflected in the functions of the various enzymes. Inhibitors (natur...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1987
ISSN: 0108-7673
DOI: 10.1107/s0108767387084125